Scarab Genomics

Scarab Genomics, an emerging CMO, has created Clean Genome E. coli, a unique, patented set of bacterial hosts for reliable, high efficiency production of protein and nucleic acid biopharmaceuticals. All troublesome genetic elements, inlcuding IS elements and cryptic phages, and many nonessential genes, have been removed from the genome, resulting in more efficient and more reliable production. Benefits include reduced mutational damage to vectors and products, elimination of contamination of nucleic acid vaccines with IS elements, and prevention of loss of fermentation batches due to phage induction. Current licensees use these hosts for production of proteins and DNA vaccines. Clean Genome E. coli is, unlike other hosts, capable of continuous production, which has been implemented as C-FlowTM. A typical 30-day C-FlowTM process yields 4.5 kg protein per month before purification at a mere 10-liter scale, dramatically reducing infrastructure requirements for substantial productio...